Correlation of Plasma and Salivary Osteocalcin Levels with Nascent Metabolic Syndrome Components with and Without Pre/Diabetes Biochemical Parameters

Pharmacy Practice

  • Nailya R. Bulatova1School of Pharmacy, University of Jordan, Amman, 11942, Jordan.
  • Violet N. Kasabri1School of Pharmacy, University of Jordan, Amman, 11942, Jordan.
  • Abla M. Albsoul1School of Pharmacy, University of Jordan, Amman, 11942, Jordan.
  • Lana Halaseh2School of Medicine, University of Jordan, Amman, 11942, Jordan.
  • Maysa Suyagh1School of Pharmacy, University of Jordan, Amman, 11942, Jordan.

Volume 22 Issue 1 Pages 1-14

DOI: 10.18549/PharmPract.2024.1.2880

Abstract

Objectives: This study aimed to compare and correlate plasma and salivary levels of cardiometabolic risk biomarkers' of pharmacotherapy (appraised using colorimetric assays), adiposity, and atherogenicity indices. Methods: 61 Nascent MetS subjects vs. 30 lean normoglycemic and healthy controls were recruited in Family Medicine outpatient clinics/Jordan University Hospital (a referral medical center). Fasting blood and saliva specimens were collected. Clinical and anthropometric variables were determined along with atherogenecity and adiposity indices. Results: Among nascent MetS (metabolic syndrome) recruits, almost half were normoglycemic, 43% were prediabetic and 8% were diabetic. Pronouncedly Glycemic (FPG and Alc) and lipid parameters (TG, HDL-C and non-HDL-C), adiposity indices (BMI, WHR, WtHR, Conicity-index, BAI, LAP, VAI) and atherogenicity indices (AIP, TC/HDL-C, LDL-C/HDL-C, non-HDL-C/HDL-C and TG/HDL-C) were higher in the nascent MetS group (P<0.05 vs. controls). Markedly among the plasma cardiometabolic risk biomarkers (P<0.05 vs. controls) in the nascent MetS group, adipolin, cathepsin S, ghrelin, irisin, LBP, leptin, and osteocalcin were higher but plasma FGF1 levels were oddly lower. Significantly (P<0.05 vs. controls) nascent MetS–linked salivary levels of adipolin and LBP were higher as opposed to the lower cathepsin S. Only osteocalcin, amongst 9 metabolic risk biomarkers studied, had remarkably significant correlation between plasma and saliva levels, in both total sample and MetS patients (P<0.05). Markedly in the nascent MetS only group, both plasma and salivary osteocalcin correlated with FPG and A1c (P<0.05); salivary osteocalcin correlated with BMI and LAP (P<0.05). Likewise, in the total sample plasma osteocalcin correlated significantly with BMI, BAI, WHt R, SBP, DBP, TG, LAP, VAI, TG/HDL-C and AIP (P<0.05), while salivary osteocalcin had substantial correlations only with FPG and A1c (P<0.05). Conclusion: Association of nascent MetS-related plasma and salivary osteocalcin levels and clinical characteristics and indices propagate salivary osteocalcin as a non-invasive marker for clinical control of MetS-/preDM.

Keywords

  • adipolin
  • cathepsin
  • FGF1 (Fibroblast growth factor 1)
  • ghrelin
  • irisin
  • klotho
  • LBP (lipopolysaccharide binding protein)
  • Leptin
  • Osteocalcin
  • adiposity and atherogenicity indices
  • cardiometabolic risk
  • nascent metabolic syndrome and prediabetes
Pharmacy Practice

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