Effect of weekly high-dose vitamin D3 supplementation on the association between circulatory FGF-23 and A1c levels in people with vitamin D deficiency: A randomized controlled 10-week follow-up trial

Pharmacy Practice

  • Sara M. Alimam1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
  • Jehad F. Alhmoud2Department of Medical Laboratory Sciences, Jordan University of Science and Technology, P.O.Box 3030, Irbid, 22110, Jordan.
  • Heba A. Khader3Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan.
  • Ahmad R. Alsayed1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
  • Mohammad Abusamak4Department Surgery, School of Medicine, Al-Balqa Applied University, As-Salt 19117, Amman Eye Clinic, Amman 11931, Jordan.
  • Beisan A. Mohammad5Pharmaceutical Sciences Department - PharmD Program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia.
  • Ibrahim Mosleh6Departments of Clinical Laboratory, University of Jordan, Amman, Jordan.
  • Khaled Abu Khadrah7Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan.
  • Ahmad Aljaberi8Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science Private University, Amman 11931, Jordan.
  • Maha Habash9Michael Sayegh, Faculty of Pharmacy, Aqaba University of Technology, Aqaba 77110, Jordan.
  • Luai Hasoun1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
  • Mahmoud S. Abu-Samak1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.

Volume 22 Issue 2 Pages 1-8

DOI: 10.18549/PharmPract.2024.2.2934

Abstract

Purpose: This randomized clinical trial (RCT) was designed to assess the effect of vitamin D supplementation (VD3) on the relationship between the levels of fibroblast growth factor-23 (FGF-23) and osteocalcin factor (OSC) with glycated hemoglobin (A1c) values in the blood in a sample of Jordanian males and female adults with vitamin D deficiency. Subjects and methods: This RCT was designed to randomly split (78) eligible participants into two groups: experimental (Group A) and interventional (Group B). Group B was supplemented with a weekly dose of 50,000 IU VD3 for eight weeks. Fasting baseline and follow-up (10 weeks; 8 weeks supplementation plus washout two weeks) of serum 25 hydroxyvitamin D (25OHD), fibroblast growth factor-23 (FGF-23), glycosylated hemoglobin (A1c), parathyroid hormone (PTH), calcium, and phosphorus were assayed. A paired T-test was used to assess the changes in fibroblast growth factor-23, A1c, and OSC levels over the follow-up period. RESULTS: Significant increase in follow-up level of 25OHD (40.04 ± 11.61 vs. 15.35 ± 5.41, PC < 0.001), FGF-23 (114.04 ± 103.8 vs. 87.40 ± 82.21, PA = 0.02) and A1c (5.63 ± 0.33 vs. 5.38 ± 0.32, PA = 0.01). Conclusion: High doses of vitamin D supplementation (50,000 IU/week) may have potentially negative effects on glycemic control, which might be related to changes in serum osteocalcin than in FGF23 levels.

Keywords

  • vitamin D deficiency
  • vitamin D3
  • fibroblast growth factor-23
  • A1c
  • OSC
Pharmacy Practice

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