Nano-Enhanced Antibiotic Delivery for Skin Cancer Treatment: A Breakthrough in Nanomedicine

Pharmacy Practice

  • Farah Alanazi1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Samar Abdulrahman2Department of Pharmacy, King Fahad Medical City Hospital, Riyadh, Saudi Arabia.
  • Osama Asiri3Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia.
  • Mohammed Alasmry3Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia.
  • Nawaf Alshahrani3Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia.
  • Saud Aseri3Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia.
  • Mohammed Abdualrahim4Department of Clinical Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
  • Raghida Almuzaini1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Ranim Alotaibi1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Ranad Babalghaith1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Lamia Abuhaimed1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Sahar Alhussain1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Raghad Aldossary1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Reema Naqqash1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Ghaida Alqahtani1Department of Clinical Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

Volume 23 Issue 2 Pages 1-19

DOI: 10.18549/PharmPract.2025.2.3117

Abstract

Skin cancer is a major global health concern for which there is a lack of efficacy in conventional treatment approaches because of systemic toxicity and low pharmaceutical efficacy, among other reasons. By enabling customized medicine delivery to cancer cells with minimal negative effects on healthy elements, nanotechnology has emerged as an effective solution to these issues. The tutorial provides an overview of current breakthroughs in nanotechnology-based medication delivery methods for treating skin cancer. Diverse kinds of nanocarriers, among them liposomes, nanoparticles, and micelles, have unique advantages such extended circulation and the capacity to encapsulate medications that are both impermeable and hydrophilic in character. These characteristics enable the exact delivery of therapeutic medications to lesions of skin cancer. Graphene, silica, and polymers are just a few of the several nanomaterials that have been utilized to construct carriers with various characteristics. Surface functionalization of nanocarriers also allows targeted distribution to cancer cells via ligand-receptor interactions or reaction to environmental stimuli. Reducing adverse effects and improving treatment effectiveness, smart nanosystems precisely boost medicine release at the tumour location. Temperature, light, and pH are just a few of the factors that affect them. Nanotechnology allows for the delivery of both conventional chemotherapeutic medications and novel treatment modalities including gene therapy, Skin radiation therapy for cancer may now be approached in a more comprehensive way thanks to immunotherapeutics and small interfering RNA (siRNA). By presenting the most recent advancements in preclinical and clinical research, this talk emphasises the potential of nanotechnology in resolving the challenges associated with skin cancer treatment. Due to its enhanced therapeutic outcomes, less systemic toxicity, and higher drug delivery efficiency, nanotechnology presents a promising approach for developing new and effective treatments for skin cancer. The ongoing research in this field has led to optimistic expectations for the future of tailored and targeted therapy for patients with skin cancer.

Pharmacy Practice

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