Treatment of Recalcitrant Dermatophytosis Using Combined Oral Acyclovir and Oral Antifungal: A Case Series

Abstract

Objective: The purpose of this study was to evaluate the efficacy of combination therapy with oral acyclovir and antifungal drugs in addressing persistent dermatophytosis, particularly in patients with viral co-infections and impaired immune systems. Methods: A prospective study was performed on eight patients with persistent fungal infections who were all treated with a combination of antifungal drugs, oral acyclovir, topical steroids, antihistamines, and supportive care. Patient outcomes were monitored over six months. Recovery time and the efficacy of preventive courses were assessed. Results: All patients were fully recovered within six months. Symptoms subsided within 2-4 weeks, and full recovery occurred in 6-8 weeks. Preventive courses helped to avoid relapses. Combining antiviral and antifungal drugs proved valuable, especially in cases of treatment resistance or recurring infections. Conclusion: The study focuses on the potential benefits of combining oral acyclovir with antifungal medications for treating recalcitrant dermatophytosis. This method is a promising strategy for improving outcomes in difficult cases, particularly for patients with viral co-infections. Further research with controlled studies is necessary to confirm these findings.