Factors affecting the patient’s knowledge, experience and medication adherence with isotretinoin: A cross sectional study among Jordanian patients

Pharmacy Practice

  • Amani Al-Rawashdeh1Faculty of Pharmacy, Amman Arab University, Amman, Jordan.
  • Raja’a A. Al-Qudah2Department of Clinical Pharmacy and Therapeutics, School of Pharmacy, Applied Science Private University, Amman, Jordan.
  • Sarah Ibrahim3School of Pharmacy, Department of Biopharmaceutics and Clinical Pharmacy, The University of Jordan, Amman, Jordan.
  • Wala’a Al.Safadi4Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman, Jordan.
  • Sarah Falah Al-Rawi5The University of Jordan Hospital, Amman, Jordan.
  • Shahad Al-Rawi5The University of Jordan Hospital, Amman, Jordan.
  • Diana Malaeb6College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates.
  • Souheil Hallit7School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, Jounieh, Lebanon.
  • Muna Barakat2Department of Clinical Pharmacy and Therapeutics, School of Pharmacy, Applied Science Private University, Amman, Jordan.

Volume 24 Issue 2 Pages 1-12

DOI: 10.18549/PharmPract.2026.2.3388

Abstract

Aim: This study aims to evaluate the factors affecting the patient’s knowledge, experience and medication adherence with isotretinoin. Methods: This cross-sectional study, conducted in Jordan from October 2023 to February 2024, utilized Google Forms to create a self-administered online survey for data collection. Multiple-linear regression analysis was conducted to study the predictors affecting knowledge, experience (using SKINDEX-16 scale) and adherence of patients to isotretinoin (using LMAS-14 scale). Results: A total of 147 responses were included in the final analysis. The majority of the study participants were females (133, 90.5%), holding bachelor’s degree (126, 85.7%), single (116, 78.9%) and living in urban areas (118, 80.3%). Study participants demonstrated a moderate level of knowledge (mean score was 14.25±3.97 out of 22), a positive experience, and adherent to isotretinoin (mean score was 4.61±2.48). The knowledge score about isotretinoin was positively affected by female gender, university education, living in urban areas, and previous experience with isotretinoin use. While patient experience with isotretinoin was positive, increasing the participant’s age. Regarding medication adherence, it was positively affected by previous experience with isotretinoin and the doctor-patient communication score. Conclusion: These findings emphasize the need for tailored interventions to improve education, communication, and support, ultimately enhancing treatment outcomes and patient satisfaction with isotretinoin therapy. Future research could explore longitudinal trends and additional factors affecting medication adherence in this context.

Keywords

  • knowledge
  • experience
  • adherence
  • isotretinoin
  • Jordan
Pharmacy Practice

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